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Treatment of interdigital tinea pedis: once-daily therapy with sertaconazole nitrate

Jeffrey M Weinberg1, Evelyn K Koestenblatt

  • 1Department of Dermatology, St. Luke's-Roosevelt Hospital Center and Beth Israel Medical Center, New York, NY, USA. jmw27@columbia.edu

Journal of Drugs in Dermatology : JDD
|October 5, 2011
PubMed

Insights

Once-daily sertaconazole nitrate 2% cream effectively treats tinea pedis, matching traditional twice-daily regimens. This "forgiving" dosing may improve patient adherence for fungal skin infections.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Patient adherence to topical antifungal therapy is crucial for treating cutaneous fungal infections.
  • Cumbersome, long-duration treatment regimens can negatively impact adherence.
  • Once-daily dosing offers a potentially more forgiving alternative to traditional twice-daily regimens.

Purpose of the Study:

  • To evaluate the efficacy of once-daily sertaconazole nitrate 2% cream compared to a twice-daily regimen for tinea pedis.
  • To assess the impact of a simplified dosing schedule on treatment outcomes and patient adherence.

Main Methods:

  • A small clinical trial involving 32 patients with tinea pedis.
  • Comparison of once-daily versus traditional twice-daily application of sertaconazole nitrate 2% cream.
  • Assessment of clinical improvement and symptom resolution over a four-week treatment period and a six-week follow-up.

Main Results:

  • Once-daily sertaconazole nitrate 2% cream demonstrated comparable efficacy to the traditional twice-daily regimen.
  • Rapid improvement in pruritus was observed by week 2.
  • At six weeks post-treatment, all patients were free of erythema, and 93.8% were free of pruritus, with no reported relapses.

Conclusions:

  • Sertaconazole nitrate 2% cream is effective when administered once daily for four weeks in treating tinea pedis.
  • A once-daily regimen may enhance patient adherence due to its simplified schedule.
  • This simplified approach shows promise for improving therapeutic outcomes in fungal skin infections.

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