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NMR studies of interactions of ligands with dihydrofolate reductase
1National Institute for Medical Research, Mill Hill, London, U.K.
Biochemical Pharmacology
|July 1, 1990
Abstract:
NMR spectroscopy is a useful technique for studying interactions, conformations and dynamic processes within ligand-protein complexes. Several examples of the application of the method to studies of complexes of anti-folate drugs with their target enzyme, dihydrofolate reductase, are discussed.