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Activation of c-Ki-ras not detectable in adenomas or adenocarcinomas arising in rat pancreas
B K Schaeffer1, J Zurlo, D S Longnecker
1Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03756.
Molecular Carcinogenesis
|January 1, 1990
Abstract:
The objective of this study was to determine whether activation of c-Ki-ras occurs in carcinogen-induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine-treated rats and corn oil-gavaged rats along with a nafenopin-induced rat pancreatic adenocarcinoma were examined for mutation of c-Ki-ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c-Ki-ras is not a common event during pancreatic carcinogenesis in the rat.