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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Incidence and descriptive epidemiologic features of traumatic brain injury in King County, Washington
Thomas D Koepsell1, Frederick P Rivara, Monica S Vavilala
1Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195-7236, USA. koepsell@u.washington.edu
Insights
Pediatric traumatic brain injuries (TBIs) are common, with most cases being mild. Incidence rates vary by age and gender, with falls being the most common cause in young children. Prevention strategies should be age-specific.
Area of Science:
- Pediatric emergency medicine
- Public health surveillance
- Neurotrauma epidemiology
Background:
- Traumatic brain injury (TBI) is a significant cause of childhood disability in the U.S.
- Accurate population-based incidence data for pediatric TBI is crucial for effective public health interventions.
- Understanding TBI incidence and mechanisms in children informs targeted prevention efforts.
Purpose of the Study:
- To determine the population-based incidence rates of medically treated traumatic brain injuries (TBIs) in children aged 0-17 years.
- To analyze TBI incidence by age group, gender, and mechanism of injury.
- To compare local TBI incidence rates with national estimates.
Main Methods:
- Conducted surveillance in a random sample of hospital emergency departments in King County, Washington.
- Included data from hospital admission logs and the medical examiner's office for comprehensive case identification.
- Interviewed parents and reviewed medical records for a subset of nonfatal cases to verify TBI, severity, and mechanisms.
Main Results:
- Estimated TBI incidence was 304 cases per 100,000 child-years.
- Incidence peaked in preschool-aged children and was lowest in children aged 5-9 years.
- Falls were the primary injury mechanism for preschoolers; older children experienced more injuries from being struck by objects or motor vehicle incidents. Boys had higher rates than girls, with a widening gap in older children. Approximately 97% of TBIs were mild.
Conclusions:
- Traumatic brain injuries result in numerous pediatric emergency department visits, with most cases being clinically mild.
- King County TBI incidence rates were lower than recent national estimates but consistent with prior U.S. studies.
- Tailored, age-specific prevention strategies are essential due to the variation in injury mechanisms across different age groups.
Objective:
Traumatic brain injury (TBI) is a major cause of disability among US children. Our goal was to obtain population-based data on TBI incidence rates.
Methods:
We conducted surveillance through a stratified random sample of hospital emergency departments in King County, Washington, to identify children 0 to 17 years of age with medically treated TBIs during an 18-month study period in 2007-2008. Additional cases were identified through hospital admission logs and the medical examiner's office. For a sample of nonfatal cases, parents were interviewed to verify TBIs, and medical record data on severity and mechanisms were obtained.
Results:
The estimated incidence of TBIs in this setting was 304 cases per 100,000 child-years. The incidence was highest for preschool-aged children and lowest for children aged 5 to 9 years. Rates were uniformly higher for boys than for girls; there was a larger gender gap at older ages. Falls were the main mechanism of injury, especially among preschool-aged children, whereas being struck by or against an object and motor vehicle-related trauma were important contributors for older children. Approximately 97% of TBI cases were mild, although moderate/severe TBI incidence increased with age.
Conclusions:
TBIs led to many emergency department visits involving children, but a large majority of the cases were clinically mild. Incidence rates for King County were well below recent national estimates but within the range reported in previous US studies. Because mechanisms of injury varied greatly according to age, prevention strategies almost certainly must be customized to each age group for greatest impact.
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