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Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Formation of Dispersible Taohong Siwu Tablets
05:44

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Published on: February 3, 2023

In vitro evaluation of domperidone mouth dissolving tablets.

S Patra1, R Sahoo, R K Panda

  • 1University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar - 751 004, India.

Indian Journal of Pharmaceutical Sciences
|October 5, 2011
PubMed
Summary

Researchers developed domperidone mouth dissolving tablets using superdisintegrants. The best formulation, F3, containing 6% crospovidone, showed rapid disintegration and high drug release within 15 minutes.

Keywords:
Crospovidonecroscarmellose sodiumdomperidonemouth dissolving tabletssodium starch glycollatesuperdisintegrants

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Formulation Development

Background:

  • Domperidone is an antiemetic and prokinetic agent.
  • Developing orally disintegrating tablets (ODTs) enhances patient compliance, especially for those with swallowing difficulties.
  • Superdisintegrants are crucial for rapid tablet disintegration in the oral cavity.

Purpose of the Study:

  • To formulate and evaluate mouth dissolving tablets (MDTs) of domperidone.
  • To investigate the effect of different superdisintegrants (crospovidone, croscarmellose sodium, sodium starch glycolate) at various concentrations (3%, 4%, 6% w/w) on MDT properties.
  • To identify the optimal formulation for rapid drug release.

Main Methods:

  • Domperidone MDTs were prepared using the direct compression method.
  • Formulations were evaluated for physical characteristics: weight variation, hardness, and friability.
  • In vitro performance was assessed through disintegration time, wetting time, and dissolution studies.

Main Results:

  • All tested superdisintegrants facilitated rapid disintegration and dissolution.
  • Formulation F3, incorporating 6% w/w crospovidone, exhibited the most favorable characteristics.
  • F3 demonstrated an in vitro disintegration time of 9 seconds and a wetting time of 15 seconds.
  • F3 achieved 99.22% in vitro drug release within 15 minutes.

Conclusions:

  • Crospovidone at 6% w/w is an effective superdisintegrant for domperidone MDTs.
  • The direct compression method is suitable for manufacturing these domperidone MDTs.
  • The optimized formulation (F3) shows potential for improved therapeutic efficacy due to rapid drug release.