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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
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Bacterial isolates in chronic suppurative otitis media: a changing pattern?

A A Adoga1, A Bakari, O A Afolabi

  • 1National Ear Care Center, No. 3 Golf/Independence Way, PMB 2438, Kaduna, Nigeria. Adeyiadoga@gmail.com

Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria
|October 6, 2011
PubMed
Summary

In Nigeria, Klebsiella, E. coli, and Streptococcus are the main causes of chronic suppurative otitis media, differing from global patterns. These bacteria show high sensitivity to quinolone antibiotics like ofloxacin.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Chronic suppurative otitis media (CSOM) is a common ear infection globally.
  • Pseudomonas aeruginosa is often the predominant pathogen in CSOM worldwide.
  • Regional variations in causative organisms necessitate localized epidemiological studies.

Purpose of the Study:

  • To identify the predominant bacterial pathogens causing CSOM in Kaduna, Nigeria.
  • To determine the in-vitro antibiotic susceptibility patterns of isolated bacteria.
  • To compare local CSOM etiology with global trends.

Main Methods:

  • A prospective study involving 97 patients with CSOM at the National Ear Care Center, Kaduna, Nigeria.
  • Bacteriological culture and identification of ear discharge isolates.
  • In-vitro antibiotic susceptibility testing of identified bacterial isolates.

Main Results:

  • Klebsiella sp. (41.3%), Escherichia coli (29.3%), and Streptococcus sp. (10.8%) were the leading pathogens, unlike the global prevalence of P. aeruginosa.
  • Gram-negative bacteria constituted 80% of all isolates.
  • All isolates demonstrated high sensitivity to ofloxacin, ciprofloxacin, and pefloxacin.

Conclusions:

  • The etiological pattern of CSOM in Kaduna, Nigeria, differs significantly from global trends.
  • Klebsiella sp., E. coli, and Streptococcus sp. are the primary causative agents in this region.
  • Quinolone antibiotics (ofloxacin, ciprofloxacin, pefloxacin) are effective treatments due to high sensitivity rates and favorable characteristics.