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Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.

Christian Brenneis1, Marco Sisignano, Ovidiu Coste

  • 1Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany. Christian.Brenneis@childrens.harvard.edu

Molecular Pain
|October 6, 2011
PubMed
Summary

Soluble epoxide hydrolase (sEH) inactivates 8,9-epoxyeicosatrienoic acid (EET), a molecule that sensitizes pain-sensing neurons. Inhibiting sEH may worsen pain during inflammation, suggesting caution when targeting this pathway for cardiovascular diseases.

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