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Primary diffuse large B-cell lymphoma of the testis.
Matthew J Horne1, Adebowale J Adeniran
1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06519, USA.
Archives of Pathology & Laboratory Medicine
|October 6, 2011
Summary
Primary testicular diffuse large B-cell lymphoma typically presents as a unilateral mass in older men. Current treatments offer limited long-term survival, highlighting a need for improved therapeutic strategies for this rare cancer.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary diffuse large B-cell lymphoma (DLBCL) of the testis is a rare extranodal non-Hodgkin lymphoma.
- It predominantly affects older male patients.
Purpose of the Study:
- To review the key aspects of testicular DLBCL.
- To discuss its clinical presentation, microscopic features, and treatment outcomes.
Main Methods:
- This is a review article based on existing literature.
- Key pathological and clinical features are summarized.
Main Results:
- Testicular DLBCL commonly presents as a unilateral testicular mass.
- Microscopic examination reveals diffuse infiltration of lymphocytes between seminiferous tubules, often with spermatogenic arrest.
- Immunohistochemistry confirms B-cell lineage.
Conclusions:
- Orchiectomy and combination chemotherapy are traditional treatments, but long-term disease-free survival is achieved in only a minority of patients.
- Differential diagnosis includes seminoma and inflammatory conditions like viral or granulomatous orchitis.
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