Related Experiment Video
Updated: May 28, 2026
10:51
Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
Published on: October 13, 2021
Biofriendly bonding processes for nanoporous implantable SU-8 microcapsules for encapsulated cell therapy
Krishnamurthy Nemani1, Joonbum Kwon, Krutarth Trivedi
1Department of Radiology, Dartmouth Medical School, Hanover, NH, USA.
Journal of Microencapsulation
|October 6, 2011
Summary
Photolithography creates robust microdevices for cell encapsulation, improving immunoisolation. Photocured bonding offers the strongest and most stable adhesion for sealing these devices under physiological conditions.
Area of Science:
- Biomaterials Science
- Microfabrication
- Immunoisolation Technology
Background:
- Photolithographic methods enable the fabrication of mechanically robust, cell-encapsulating microdevices.
- These microdevices offer potential for more efficient immunoisolation compared to traditional cell-encapsulating hydrogels.
- A critical need exists for effective adhesive bonding methods to seal these microdevices under physiologically compatible conditions.
Purpose of the Study:
- To evaluate different adhesive bonding techniques for sealing SU-8 based microdevices.
- To identify a method suitable for long-term applications requiring stable and robust sealing.
- To compare magnetic self-assembly, moisture-cured bonding, and photocured bonding.
Main Methods:
- Investigated magnetic self-assembly in aqueous buffers.
- Assessed moisture-cured bonding of covalently modified SU-8 substrates via silanol condensation.
- Evaluated photocured bonding using a medical-grade adhesive on acrylate-modified substrates.
Main Results:
- Magnetic self-assembly yielded weak bonding, unsuitable for long-term use.
- Moisture-cured bonding resulted in weak and inconsistent adhesion.
- Photocured bonding demonstrated stable and robust adhesion, outperforming other methods.
Conclusions:
- Photocured bonding using a medical-grade adhesive is the most effective method for sealing SU-8 microdevices.
- This technique provides strong and stable adhesion under physiological conditions.
- The developed method is crucial for advancing cell encapsulation and immunoisolation technologies.
