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Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis
Aurore Muselier1, Philip Bielefeld, Samuel Bidot
1Ophthalmology Department, University Hospital, Dijon, France.
Purpose:
To report on two patients with refractory uveitis treated with tocilizumab; a new humanized monoclonal antibody against the interleukin-6 receptor (IL-6R).
Design:
Retrospective interventional case series.
Methods:
Both patients received a monthly infusion of tocilizumab 8 mg/kg; associated with corticosteroids. Outcome measures were visual acuity and central retinal thickness evaluated with optical coherence tomography.
Results:
An improvement in visual acuity and a decrease in macular edema were observed in these two patients.
Conclusions:
Tocilizumab seems to be a promising treatment in refractory uveitis. A prospective study is needed to evaluate the role of this new agent in the management of refractory uveitis.
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