Related Experiment Video
Updated: Feb 9, 2026
10:54
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
Published on: November 21, 2025
486
Optimization of conventional therapy in patients with IBD
Kirstin M Taylor1, Peter M Irving
1Department of Gastroenterology, Guy's & St Thomas' Hospitals, Westminster Bridge Road, London SE1 7EH, UK.
Nature Reviews. Gastroenterology & Hepatology
|October 6, 2011
Summary
Optimizing conventional therapies for Inflammatory Bowel Disease (IBD) is crucial. This review details strategies to improve drug adherence and effectiveness, avoiding premature abandonment of treatments and unnecessary exposure to biologics.
Area of Science:
- Gastroenterology
- Pharmacology
- Internal Medicine
Background:
- Most Inflammatory Bowel Disease (IBD) patients use conventional therapies (aminosalicylates, antibiotics, corticosteroids, immunomodulators) long-term for remission induction and maintenance.
- IBD treatment paradigms are shifting towards rapid escalation to achieve goals like mucosal healing and reduced hospitalizations/surgery.
Purpose of the Study:
- To provide an overview of optimizing conventional therapy in IBD management.
- To describe strategies for improving patient adherence to drug regimens.
Main Methods:
- Review of current literature on conventional IBD therapies.
- Analysis of strategies for optimizing drug regimens, delivery, and dosing.
- Exploration of personalized medication approaches based on metabolite levels.
Main Results:
- Failure to optimize conventional therapy can lead to its premature abandonment.
- Optimized conventional treatments can prevent unnecessary exposure to potentially toxic or expensive biologic drugs.
- Strategies include simplifying dosing, optimizing drug delivery and dose, and tailoring medication.
Conclusions:
- Optimizing conventional therapy is essential for effective IBD management.
- Improved adherence and tailored medication can enhance treatment outcomes.
- Maximizing conventional therapies can reduce reliance on biologics and improve patient care.
Related Concept Videos
01:30Sign Convention
3.5K
When analyzing a beam subjected to various loads, it is crucial to understand the internal forces and moments generated within the structure. These internal forces can be broadly classified into normal forces, shear forces, and bending moments. To determine these forces and moments, we use the method of sections and apply a specific sign convention based on their direction and the side of the section being analyzed.
The normal force acts perpendicular to the beam's cross-section and can...
The normal force acts perpendicular to the beam's cross-section and can...
3.5K
01:29Drugs for Treatment of Ulcerative Colitis in IBD
527
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
527
01:15Enolate Mechanism Conventions
2.9K
When a carbonyl compound is treated with a strong base, the α position gets deprotonated to give a resonance-stabilized intermediate called an enolate. Enolates are ambident nucleophiles because they possess two nucleophilic sites that can attack an electrophile owing to the delocalization of the negative charge between the α carbon and oxygen atoms. When the oxygen atom attacks an electrophile, it is called O-attack, whereas electrophilic attack via the α carbon is known as...
2.9K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
518
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
518
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
00:48Optimal Foraging
13.9K
How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
13.9K