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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 28, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Severe osteoporosis and its identification.

Giovanni Iolascon1, Giuseppina Resmini, Francesca Gimigliano

  • 1Department of Orthopedics and Rehabilitation, Second University of Naples, 80138 Naples, Italy. giovanni.iolascon@unina2.it

Aging Clinical and Experimental Research
|October 6, 2011
PubMed
Summary

Osteoporosis severity involves more than bone density, including increased mortality risk, reduced quality of life, disability, and fragility fractures. Early identification of these factors is crucial for managing osteoporosis.

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Published on: January 31, 2025

Area of Science:

  • Gerontology
  • Orthopedics
  • Public Health

Background:

  • Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration.
  • Current diagnostic criteria primarily rely on bone mineral density (BMD) measurements.

Purpose of the Study:

  • To expand the understanding of osteoporosis severity beyond densitometric data.
  • To identify key clinical indicators associated with severe osteoporosis.

Main Methods:

  • This study reviewed existing literature and clinical guidelines on osteoporosis assessment.
  • Key indicators evaluated included mortality risk, quality of life, functional disability, comorbidities, and fragility fractures.

Main Results:

  • Osteoporosis severity is multifactorial, encompassing increased mortality risk.
  • Worsened quality of life and significant disability in daily activities are critical indicators.
  • Comorbidities heightening fall risk and the occurrence of fragility fractures are essential markers.

Conclusions:

  • Accurate osteoporosis severity assessment requires integrating densitometric data with clinical outcomes.
  • Recognizing these broader clinical parameters is vital for comprehensive patient management and intervention strategies.