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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Bone as Supporting Connective Tissue

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Bone Cells and Tissue

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A comparison of clinical and radiologic outcomes of intra-articular calcaneal fracture treatment with the Ilizarov method and internal fixation - a two-center study.

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Updated: May 28, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Biomaterials and bone.

Daniele Pili1, Paolo Tranquilli Leali

  • 1AOU, Clinica Ortopedica, Università degli Studi di Sassari, Viale San Pietro, Italy.

Aging Clinical and Experimental Research
|October 6, 2011
PubMed
Summary

Currently, no ideal bone healing biomaterials exist. This review examines current bone surgery biomaterials, focusing on their biological properties and compatibility for optimal patient outcomes.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Tissue Engineering

Background:

  • Bone healing involves complex biochemical, biomechanical, cellular, hormonal, and pathological mechanisms.
  • Ideal biomaterials that perfectly replicate these natural healing processes are not yet available.
  • Current limitations necessitate careful selection of existing biomaterials for bone regeneration.

Purpose of the Study:

  • To provide an overview of biomaterials utilized in contemporary bone surgery.
  • To analyze the biological properties and compatibility of these bone graft materials.
  • To guide the selection of appropriate biomaterials based on specific clinical needs.

Main Methods:

  • Literature review of current biomaterials in bone surgery.

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Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biological Compatibility Profile on Biomaterials for Bone Regeneration

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Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo

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Half-segmental Diaphyseal Bone Defect Model in Rats for Evaluating Bone Substitute Performance in Load-bearing Regions

Published on: December 30, 2025

  • Analysis of biological properties (e.g., osteoconductivity, osteoinductivity).
  • Evaluation of biocompatibility and host tissue response.

    • Main Results:

    • Overview of various synthetic and natural biomaterials used for bone defect repair.
    • Discussion of the advantages and disadvantages of each material class.
    • Comparison of biological performance and integration with host bone.

    Conclusions:

    • No single biomaterial currently meets all ideal requirements for bone healing.
    • Careful consideration of biomaterial properties is crucial for successful orthopedic interventions.
    • Ongoing research aims to develop advanced biomaterials that better support bone regeneration.