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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 28, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Total hip arthroplasty and bone fragility.

Paolo Cherubino1, Chiara Ratti, Alessandro Fagetti

  • 1Orthopaedic and Trauma Institute, Universitas Studiorum Insubriae, Varese, Italy. clinica.ortopedica@ospedale.varese.it

Aging Clinical and Experimental Research
|October 6, 2011
PubMed
Summary
This summary is machine-generated.

The aging population is increasing the need for hip replacements. Challenges like osteoporosis in elderly patients can complicate implant fixation and surgical outcomes.

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Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

Related Experiment Videos

Last Updated: May 28, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

Area of Science:

  • Orthopedics
  • Gerontology
  • Biomaterials Science

Background:

  • The global elderly population is rapidly expanding, leading to a projected rise in osteoarthritis cases and subsequent demand for total hip arthroplasties.
  • Elderly patients frequently have compromised bone quality, such as osteoporosis, characterized by reduced bone mass and increased fragility, complicating implant fixation.

Purpose of the Study:

  • To highlight the increasing need for total hip arthroplasties due to demographic shifts.
  • To discuss the challenges in achieving stable implant fixation in elderly patients with compromised bone quality.
  • To explore the implications of osteoporosis on prosthetic surgery and implant osteointegration.

Main Methods:

  • Review of demographic trends and their impact on orthopedic surgery projections.
  • Analysis of bone tissue changes associated with aging and osteoporosis.
  • Discussion of surgical fixation techniques (cemented vs. cementless) and their suitability for elderly patients.

Main Results:

  • The increasing prevalence of elderly individuals necessitates a greater number of hip replacement surgeries.
  • Osteoporotic bone presents significant challenges for primary implant stability and increases the risk of intraoperative fractures.
  • Bone stock deficiencies in revision surgeries further complicate implant fixation, particularly distal stem placement.

Conclusions:

  • Optimal preoperative planning, considering bone quality, is crucial for successful total hip arthroplasty in the aging population.
  • The long-term effects of osteoporosis medications on implant osteointegration require further investigation.
  • Addressing the unique challenges of elderly patients is essential for improving outcomes in hip arthroplasty and revision surgery.