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Related Experiment Video

Updated: May 28, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

Integrated Oxygenator FX05.

Stephen B Horton¹, Susan Donath, Clarke A Thuys

¹Department of Cardiac Surgery, Royal Children's Hospital, Australia. steve.horton@rch.org.au

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|October 6, 2011

Summary

This summary is machine-generated.

The new FX05 oxygenator effectively removes emboli during cardiopulmonary bypass (CPB), performing similarly to the traditional setup with a separate arterial filter. This integrated design simplifies circuits and reduces prime volume.

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Last Updated: May 28, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

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Published on: May 4, 2021

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Published on: October 31, 2025

Area of Science:

Cardiovascular Surgery
Biomedical Engineering
Medical Device Technology

Background:

Arterial filters are increasingly integrated into cardiopulmonary bypass (CPB) oxygenators.
The FX oxygenators represent a novel design integrating filtration within the oxygenator fibers.

Purpose of the Study:

To compare the embolic load reduction efficacy of the integrated FX05 oxygenator against a conventional setup (RX05 oxygenator plus an arterial filter).
To evaluate the FX05 oxygenator's performance in a clinical setting for patients undergoing CPB.

Main Methods:

A randomized trial assigned 40 patients undergoing CPB to either the FX05 oxygenator or the RX05 oxygenator with an arterial filter.
Embolic load was quantified using pre- and post-filter/oxygenator sensors.
Data analysis involved analyzing prefilter embolic volumes divided into deciles due to skewed distribution.

Main Results:

Both the FX05 oxygenator and the conventional RX05 + arterial filter setup demonstrated high percentages of prefilter embolic load removal.
The devices performed similarly in filtering out emboli.
No significant difference in embolic filtration efficacy was observed between the two setups.

Conclusions:

The FX05 oxygenator is clinically as effective as the conventional RX05 oxygenator with an arterial filter in removing emboli during CPB.
The integrated design of the FX05, along with prime volume reduction and circuit simplification, supports its adoption.