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Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney
Przemyslaw Rutkowski1, Tomasz Sledzinski, Hanna Zielinska
1Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Regulatory Peptides
|October 6, 2011
Summary
Kidney transplantation significantly lowers elevated serum chemerin levels in end-stage renal disease (ESRD) patients. This normalization of chemerin, an inflammation marker, correlates with improved kidney function post-transplant.
Area of Science:
- Biochemistry
- Nephrology
- Immunology
Background:
- Chemerin, an adipokine, is linked to metabolic syndrome, inflammation, and the immune system.
- Decreased renal function may elevate serum chemerin concentrations.
- End-stage renal disease (ESRD) patients often exhibit elevated chemerin levels.
Purpose of the Study:
- To investigate the impact of kidney transplantation on serum chemerin levels in ESRD patients.
- To assess the relationship between serum chemerin and renal function markers before and after transplantation.
Main Methods:
- Studied 25 ESRD patients undergoing kidney transplantation, measuring serum chemerin pre- and post-transplant.
- Included a control group of 21 healthy subjects.
- Utilized ELISA for serum chemerin measurement and analyzed clinical status and renal function biomarkers.
Main Results:
- Kidney transplantation led to a significant decrease in serum chemerin concentrations.
- Post-transplant, serum creatinine, BUN, phosphate, and CRP levels decreased.
- eGFR, calcium, and hemoglobin levels significantly increased after transplantation.
- Serum chemerin positively correlated with creatinine and phosphate, and negatively with eGFR.
Conclusions:
- Serum chemerin concentration normalizes after kidney transplantation in ESRD patients.
- These findings support the association between serum chemerin levels and renal function.
- Kidney transplantation effectively improves markers of inflammation and renal function in ESRD.
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