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Updated: May 28, 2026
02:49
A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
An optimized animal model for partial and total skin thickness burns studies
Ana Paula Bomfim Soares Campelo1, Marcio Wilker Soares Campelo, Gerly Anne de Castro Britto
1Department of Surgery, Federal University of Ceara, Fortaleza-CE, Brazil.
Acta Cirurgica Brasileira
|October 6, 2011
Summary
This study presents an inexpensive and reproducible rat model for creating controlled thermal skin burns. The model allows for the induction of partial or full-thickness burns, aiding burn research.
Area of Science:
- Wound healing research
- Experimental animal models
- Dermatology
Background:
- Accurate animal models are crucial for studying burn pathophysiology and treatment.
- Existing models may lack reproducibility or control over burn depth.
Purpose of the Study:
- To develop and validate an improved, cost-effective, and reproducible animal model for inducing controlled thermal skin burns in rats.
Main Methods:
- Wistar rats were subjected to controlled thermal burns (100°C, 150°C, 200°C) using a heated copper plate.
- Four standardized burn areas (10x10 mm each) were created on the dorsal skin.
- Analgesia was administered post-injury.
Main Results:
- 100°C and 150°C induced partial-thickness burns with varying degrees of reepithelialization.
- 200°C resulted in full-thickness skin injury without central reepithelialization.
- Marginal reepithelialization was observed across all burn groups.
Conclusions:
- The developed model provides a reliable method for creating controlled partial or full-thickness skin burns in rats.
- This inexpensive and easily reproducible model facilitates experimental burn research.
