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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Paternal postpartum mood: bipolar episodes?
Karen Amaral Tavares Pinheiro1, Fabio Monteiro da Cunha Coelho, Luciana de Ávila Quevedo
1Postgraduate Program in Health and Behavior, Universidade Católica de Pelotas, Pelotas, RS, Brazil.
Insights
Bipolar and depressive episodes are common in fathers during pregnancy and postpartum. Men experiencing depressive symptoms antenatally should be screened for manic and hypomanic symptoms.
Area of Science:
- Psychiatry
- Maternal and Child Health
- Epidemiology
Background:
- Paternal mental health is crucial for family well-being.
- Limited research exists on paternal bipolar and depressive episodes during the perinatal period.
Purpose of the Study:
- To determine the prevalence of depressive and bipolar spectrum episodes in fathers during pregnancy, postpartum, and 12 months after childbirth.
- To investigate the association between depressive and manic/hypomanic episodes over time.
Main Methods:
- A longitudinal study followed 739 fathers in Pelotas, Brazil.
- Paternal psychopathology was assessed using the Mini Neuropsychiatric Interview (MINI) at three time points: antenatal, 30-60 days postpartum, and 12 months postpartum.
Main Results:
- Prevalence of depressive episodes was 5.0% (antenatal), 4.5% (postpartum), and 4.3% (12 months).
- Mixed episodes accounted for a significant proportion of depression cases, particularly antenatally (61.1%).
- Depressive and manic/hypomanic episodes were associated during pregnancy and postpartum, but not at 12 months.
Conclusions:
- Bipolar episodes are common in fathers with depressive symptoms during pregnancy and postpartum.
- Routine screening for manic and hypomanic symptoms is recommended for this population.
- Paternal mental health monitoring is essential throughout the perinatal period.
Objective:
We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth.
Method:
A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI) across three time points: between 28 and 34 weeks of pregnancy (T1), 30 to 60 days postpartum (T2), and 12 months after childbirth (T3).
Results:
The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth.
Conclusion:
Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.
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