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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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Published on: June 6, 2011

Drug shortage.

Crystal Conde

    Texas Medicine
    |October 6, 2011
    PubMed
    Summary
    This summary is machine-generated.

    A record 246 drugs, including essential medications like calcium gluconate and propofol, are experiencing shortages tracked by the U.S. Food and Drug Administration (FDA). These critical drug shortages raise significant concerns for Texas physicians regarding patient safety and care quality.

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    Area of Science:

    • Pharmacology and Public Health
    • Healthcare Management

    Background:

    • The U.S. Food and Drug Administration (FDA) tracks an expansive list of drug shortages.
    • As of June, a record 246 drugs were reported to be in short supply.

    Purpose of the Study:

    • To highlight the current extent of drug shortages in the United States.
    • To underscore the concerns of healthcare professionals, particularly physicians in Texas, regarding patient safety and quality of care due to these shortages.

    Main Methods:

    • Analysis of data from the U.S. Food and Drug Administration (FDA) on drug supply status.
    • Monitoring of reported drug shortages, including specific examples of commonly used medications.

    Main Results:

    • A record number of 246 drugs were in short supply as of June.
    • The list of shortages includes essential medications such as calcium gluconate, neostigmine, propofol, epinephrine, and furosemide, alongside sterile injectables and antibiotics.

    Conclusions:

    • The current drug shortage crisis poses a significant threat to patient safety and the quality of healthcare delivery.
    • Texas physicians are particularly worried about the implications of these widespread shortages on their ability to provide adequate patient care.