Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function.

Rosemari Otton¹, Douglas Popp Marin, Anaysa Paola Bolin

¹Postgraduate Program, Health Sciences, CBS, Cruzeiro do Sul University, Sao Paulo, SP, Brazil. rosemari.otton@cruzeirodosul.edu.br

European Journal of Nutrition

|October 6, 2011

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of Epicatechin Supplementation on Plasma Proteome Profiles in Obese Men and Women-An Exploratory Approach to Sexual Dimorphism.

Proteomics. Clinical applications·2025

Same author

Does Green Tea Ameliorate Obesity in Mice Kept at Thermoneutrality by Modulating Skeletal Muscle Metabolism?

Cell biochemistry and function·2025

Same author

Are glyphosate or glyphosate-based herbicides linked to metabolic dysfunction-associated steatotic liver disease (MASLD)? The weight of current evidence.

Environmental toxicology and pharmacology·2025

Same author

Transcriptomic implications of low herbicide concentrations in hepatic cells: Insights into the individual and combined effects of 2,4-D, glyphosate, and AMPA.

Toxicology letters·2025

Same author

Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes.

Journal of cellular physiology·2024

Same author

Long-term glucocorticoid infusion impairs epididymal adipocyte metabolism and maturation and affects miR-150-5p actions.

Molecular and cellular endocrinology·2024

Fish oil (FO) with astaxanthin (ASTA) supplementation reduced lymphocyte oxidative stress and enhanced immune modulation in rats. This combination may prevent negative effects of polyunsaturated fatty acids on immune cells.

Area of Science:

Immunology
Nutritional Science
Biochemistry

Background:

n-3 polyunsaturated fatty acids from fish oil (FO) offer cardiovascular and neuroprotective benefits.
Their impact on redox metabolism and lymphocyte function requires further investigation.

Purpose of the Study:

To investigate the effects of FO and astaxanthin (ASTA) on rat lymphocyte redox metabolism and function.
To assess the combined impact of FO and ASTA on immune cell properties.

Main Methods:

Lymphocyte proliferation, reactive oxygen species (ROS) production (superoxide, hydrogen peroxide), and nitric oxide generation were measured.
Oxidative damage, antioxidant enzyme activities, and cytokine release were assessed in lymphocytes.

Main Results:

Related Experiment Videos

FO + ASTA supplementation reduced lymphocyte proliferation and ROS/nitric oxide production.
Antioxidant enzyme activities and calcium release increased, while oxidative damage decreased.
ASTA mitigated FO-induced oxidative stress, and modulated specific immune markers like L-selectin and IL-1β.

Conclusions:

Combining astaxanthin with fish oil is a promising strategy to counteract oxidative stress induced by polyunsaturated fatty acids.
This synergistic approach can enhance the immunomodulatory effects of fish oil.