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Updated: May 28, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Stromal cell derived factor-1α enhances bone formation based on in situ recruitment: a histologic and histometric
Xiaoqi Liu1, Shifeng Zhou, Yanjing Li
1Department of Orthopedic Surgery, The First Affiliated Hospital, Harbin Medical University, 23Youzheng St, Nan Gang District, Harbin, 150001, People's Republic of China.
Abstract:
Histological methods were used to assess whether in situ recruitment using stromal cell derived factor-1α (SDF-1α) enhances bone formation. Four defects were created in the calvarias of 16 rabbits and filled with: (1) a blood clot only (group C); (2) autogenous bone particles (AB, 0.2 ml) (group AB); (3) AB (0.1 ml) + bone marrow derived stromal stem cells (group ABC); or (4) AB (0.1 ml) + SDF-1α (group ABS). Bone formation was significantly greater in groups AB and ABC compared with group ABS after 2 weeks (P < 0.05). Bone formation was similar between groups AB, ABC, and ABS after 4 weeks (P > 0.05). SDF-1α is a promising candidate for in situ recruitment in bone regeneration.
