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Pain in amyotrophic lateral sclerosis: a population-based controlled study.

A Chiò1, A Canosa, S Gallo

  • 1ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy. achio@usa.net

European Journal of Neurology
|October 7, 2011
PubMed
Summary

Pain is significantly more common in patients with amyotrophic lateral sclerosis (ALS) than in the general population, often impacting daily life and requiring treatment. Despite its frequency, pain in ALS is frequently underrecognized and undertreated.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Epidemiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Pain is a common but often overlooked symptom in ALS patients.

Purpose of the Study:

  • To determine the prevalence and characteristics of pain in patients with ALS.
  • To compare pain experiences between ALS patients and population-based controls.

Main Methods:

  • A cohort of 160 ALS patients from Torino, Italy, was interviewed.
  • Pain was assessed using the Brief Pain Inventory.
  • Controls were randomly selected from general practitioner lists.

Main Results:

  • Pain was reported more frequently by ALS patients (56.9%) than controls (33.1%).
  • Pain in ALS correlated with poorer functional status and longer disease duration, often affecting extremities.
  • ALS patients experienced greater interference in life enjoyment and social relations due to pain and were more likely to receive pain treatment.

Conclusions:

  • Pain is prevalent across all stages of ALS and significantly more common than in the general population.
  • Pain in ALS is often underrecognized and undertreated.
  • Further research is needed to elucidate pain mechanisms and optimal treatment strategies in ALS.