Related Experiment Video
Updated: May 28, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Variations in serum 25-hydroxyvitamin D during acute pancreatitis: an exploratory longitudinal study
Ulrich C Bang1, Srdan Novovic, Anders Møller Andersen
1Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark. ulrichbangbang@gmail.com
Endocrine Research
|October 7, 2011
Summary
Acute inflammation, such as pancreatitis, significantly lowers 25-hydroxyvitamin D3 (25OHD) levels within two days. This suggests the body utilizes 25OHD during severe inflammatory responses.
Area of Science:
- Endocrinology
- Nutritional Science
- Critical Care Medicine
Background:
- Vitamin D plays a crucial role in immune function.
- Acute inflammatory conditions can impact various metabolic processes.
- The behavior of 25-hydroxyvitamin D3 (25OHD) during acute inflammation is not fully understood.
Purpose of the Study:
- To investigate changes in 25-hydroxyvitamin D3 (25OHD) levels during acute inflammation in humans.
- To test the hypothesis that 25OHD levels decrease during acute inflammatory states.
Main Methods:
- A cohort of patients experiencing their first episode of acute pancreatitis was enrolled.
- Blood samples were collected from patients upon admission and on days 1, 2, and 14.
Main Results:
- On admission, a significant proportion of patients presented with vitamin D deficiency or insufficiency (23% severely deficient, 20% deficient, 40% insufficient).
- A significant linear decline in 25OHD, albumin, and hemoglobin was observed from day 0 to day 2.
- The decrease in 25OHD levels correlated with changes in C-reactive protein, an inflammatory marker.
Conclusions:
- 25OHD levels dropped significantly within the first two days of acute pancreatitis, exceeding expected levels based on its half-life.
- This study supports the hypothesis that acute inflammation leads to the utilization of 25OHD.
- Other unelucidated mechanisms may also influence 25OHD levels during inflammation.
More Related Videos
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Related Concept Videos
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...