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Serum FGF-21 levels in type 2 diabetic patients
Xingbo Cheng1, Bei Zhu, Fusong Jiang
1Department of Endocrinology & Metabolism, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. mcheng1982@yahoo.com
Endocrine Research
|October 7, 2011
Summary
Serum Fibroblast Growth Factor-21 (FGF-21) levels are elevated in type 2 diabetes mellitus (T2DM) patients. FGF-21 correlates with key cardiometabolic risk factors and may contribute to T2DM development.
Area of Science:
- Endocrinology
- Metabolic Research
- Diabetes Mellitus Research
Background:
- Fibroblast Growth Factor-21 (FGF-21) is a metabolic regulator with an incompletely understood physiological role.
- Investigating FGF-21 in type 2 diabetes mellitus (T2DM) is crucial for understanding metabolic dysregulation.
Purpose of the Study:
- To measure serum FGF-21 levels in T2DM patients and normal controls.
- To explore correlations between serum FGF-21 and cardiometabolic parameters in humans.
Main Methods:
- Serum FGF-21 levels were quantified using ELISA in 54 newly diagnosed T2DM, 54 long-duration T2DM, and 35 control subjects.
- Anthropometric data, glucose, HbA1c, lipids, insulin, and hsCRP were measured.
Main Results:
- Serum FGF-21 was significantly higher in T2DM patients (newly diagnosed and long-duration) compared to controls (p < 0.01).
- FGF-21 positively correlated with age, waist-to-hip ratio, blood pressure, glucose, HbA1c, HOMA-IR, and hsCRP; negatively with HOMA-B.
- Fasting insulin, HOMA-IR, LDL cholesterol, and hsCRP were independent predictors of serum FGF-21, which was significantly associated with T2DM.
Conclusions:
- Serum FGF-21 levels are elevated in T2DM patients.
- Increased FGF-21 may play a role in the pathogenesis of type 2 diabetes mellitus.
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