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Cognitive function in hypertensives treated with atenolol or propranolol
D M Palac1, R D Cornish, W J McDonald
1Veterans Administration Medical Center, Portland, Oregon 97207.
Journal of General Internal Medicine
|July 1, 1990
Summary
Beta blockers like atenolol and propranolol do not significantly impair cognitive function or cause psychiatric side effects in male veterans. Cognitive performance was unaffected in most tests, with improvement in one and minor impairment in another.
Area of Science:
- Cardiovascular Pharmacology
- Neuropsychology
Background:
- Beta blockers are widely prescribed for hypertension.
- Concerns exist regarding potential cognitive and psychiatric side effects, particularly with lipophilic agents like propranolol.
Purpose of the Study:
- To investigate the impact of atenolol and propranolol on cognitive function and psychiatric status.
- To evaluate whether lipophilic beta blockers cause cognitive impairment or psychiatric disturbances.
Main Methods:
- Randomized, double-blind, controlled crossover trial.
- 42 male veterans with diastolic blood pressure (DBP) 90-110 mmHg received propranolol-LA or atenolol.
- Dosage was titrated to achieve DBP ≤ 90 mmHg; hydrochlorothiazide was added if needed.
Main Results:
- Cognitive performance was not affected in 7 of 9 tests; enhanced on Trail Making Test.
- Digit Cancellation test showed impairment; no significant changes in anxiety or depression.
- Neither atenolol nor propranolol significantly impacted cognitive function or psychiatric measures.
Conclusions:
- Atenolol and propranolol therapy do not impair cognitive function.
- These beta blockers do not significantly contribute to psychiatric side effects.
- Findings suggest current beta blockers are safe regarding cognitive and psychiatric domains.
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