Evaluation of fetal renal function: unreliability of fetal urinary electrolytes

In the fetus with bilateral hydronephrosis it has been reported that a normal volume of amniotic fluid, absence of renal cortical cysts, urinary sodium less than 100 mEq./l., chloride less than 90 mEq./l. and osmolarity less than 210 mOsm. are prognostic factors indicative of good renal function, whereas oligohydramnios, cortical cysts and higher urinary levels of sodium, chloride or osmolarity suggest irreversible renal dysplasia. We report 5 cases in which the fetal urinary electrolytes were not predictive of ultimate renal function. In 3 instances fetal urinary electrolytes and osmolarity were abnormally elevated but the infants survived without ventilatory support. In 2 of these 3 patients the volume of amniotic fluid was normal. Diagnoses included posterior urethral valves, prune belly variant and bilateral ureteropelvic junction obstruction. In 2 cases with oligohydramnios fetal urinary electrolytes were suggestive of satisfactory renal function but the infants died of pulmonary hypoplasia and had bilateral renal dysplasia, prune belly syndrome and urethral atresia. Presently, the volume of amniotic fluid remains the most important prognostic sign in the fetus with bilateral hydronephrosis. Further work is necessary to identify other factors that may be more reliable as prognostic indexes of fetal renal function.