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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
Granulomatous interstitial nephritis associated with disseminated histoplasmosis in an immunocompetent patient
Qi Qian1, Hamid Humayun, Youshay Humayun
1Division of Hypertension and Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
We present a case of a 64-year-old man with a prolonged history of fatigue, weight loss, fever, and kidney failure. Kidney biopsy showed severe granulomatous interstitial nephritis with numerous giant cells. Silver stains identified fungal micro-organisms consistent with Histoplasma species. Despite antifungal treatment, the patient died of overwhelming infection a few weeks later. This report emphasizes the importance of diagnosing histoplasmosis early. A high degree of suspicion is required to make the diagnosis of histoplasmosis in a case of granulomatous interstitial nephritis.
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