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Updated: May 28, 2026
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
Automated synthesis of [18F]gefitinib on a modular system
Tilman Läppchen1, Maria L H Vlaming, Erica Custers
1Philips Research Europe, Department of Biomolecular Engineering, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands. tilman.lappchen@philips.com
Abstract:
In recent years, [(18)F]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [(18)F]gefitinib in 17.2±3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity >99% in a total synthesis time of about 2.5h.
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