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Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
Published on: May 24, 2024
[Paraoxonase: its multiple functions and pharmacological regulation]
Osvaldo Fridman1, Alicia Graciela Fuchs, Rafael Porcile
1Centro de Altos Estudios en Ciencias Humanas y de la Salud. Universidad Abierta Interamericana. Área de Investigación. Instituto de Oncología Ángel H. Roffo. Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas. Argentina.
Archivos De Cardiologia De Mexico
|October 7, 2011
Summary
Homocysteine contributes to atherosclerosis. The enzyme paraoxonase-1 (PON1) protects against this by preventing lipoprotein oxidation and hydrolyzing homocysteine thiolactone (HcyT).
Area of Science:
- Biochemistry
- Vascular Biology
- Enzymology
Context:
- Homocysteine is a risk factor for atherosclerosis and thrombosis.
- Homocysteine thiolactone (HcyT) is a reactive form incorporated into proteins, causing toxicity and atherogenesis.
- Paraoxonase-1 (PON1), an HDL-associated enzyme, has roles beyond organophosphate hydrolysis.
Purpose:
- To review the protective role of PON1 against atherosclerosis.
- To explore PON1's mechanisms in preventing vascular disease.
- To update on clinical and experimental findings regarding PON1 and atherosclerosis.
Summary:
- PON1 protects against atherosclerosis by preventing lipoprotein oxidation and hydrolyzing HcyT.
- PON1 activity is modulated by genetic factors, lifestyle, and medications.
- Evidence supports PON1's protective role in vascular disease.
Impact:
- Understanding PON1's function aids in developing strategies against atherosclerosis.
- Highlights PON1 as a potential therapeutic target for vascular protection.
- Provides insights into the complex interplay of factors influencing PON1 activity and vascular health.
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