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Updated: May 28, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome
J Mestres1, S A Seifert, T I Oprea
1Chemogenomics Laboratory, IMIM-Hospital del Mar and University Pompeu Fabra, Barcelona, Spain.
Abstract:
The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this context, evidence is provided here that cyclobenzaprine blocks the serotonin and norepinephrine transporters and binds to another set of five serotonin receptors. SS should be considered when indicative signs occur in the context of cyclobenzaprine use.
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