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Updated: May 28, 2026
10:18
Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Evolutionary mechanisms of retroviral persistence
James B Whitney1, So-Yon Lim, Mark A Wainberg
1Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. jwhitne2@bidmc.harvard.edu
AIDS Reviews
|October 7, 2011
Summary
Retroviruses possess genomic pliancy due to error-prone replication, aiding survival through immune evasion and persistent reservoirs. Understanding these mechanisms is crucial for eradicating Human Immunodeficiency Virus type 1 (HIV-1).
Area of Science:
- Virology
- Genomics
- Immunology
Background:
- Retroviruses demonstrate significant genomic pliancy, often linked to errors during replication.
- These viral errors are increasingly recognized as vital for survival mechanisms.
Purpose of the Study:
- To explore the dynamic mechanisms underlying retroviral persistence.
- To understand how genomic pliancy contributes to viral survival and reservoir formation.
- To inform strategies for Human Immunodeficiency Virus type 1 (HIV-1) eradication.
Main Methods:
- Review of existing evidence on retroviral replication fidelity.
- Analysis of studies investigating viral immune evasion and tropism.
- Examination of factors contributing to persistent retroviral reservoirs.
Main Results:
- Genomic errors in retroviral replication are essential for viral adaptation and survival.
- Mechanisms include immune evasion, altered cellular tropism, and compartmentalized reservoirs.
- These factors collectively facilitate long-term viral persistence.
Conclusions:
- Retroviral genomic pliancy, driven by replication errors, is a key factor in viral persistence.
- Understanding these adaptive strategies is paramount for developing effective HIV-1 eradication therapies.
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