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Updated: May 28, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Non-pharmacological management of infant and young child procedural pain
Rebecca R Pillai Riddell1, Nicole M Racine, Kara Turcotte
1Department of Psychology, York University, 4700 Keele Street, OUCH Laboratory, Atkinson College, Toronto, Ontario, Canada, M3J 1P3.
Insights
Non-pharmacological interventions like non-nutritive sucking, kangaroo care, and swaddling effectively manage acute pain and distress in infants. These methods show significant improvements in pain reactivity and regulation across preterm, neonate, and older infant age groups.
Area of Science:
- Pediatrics
- Pain Management
- Neonatal Care
Background:
- Infant acute pain and distress are common, with potential long-term health implications.
- Early life experiences significantly shape development across the lifespan.
Purpose of the Study:
- To evaluate non-pharmacological pain management strategies for infants up to three years old.
- To analyze intervention efficacy based on infant age and pain response.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) and RCT cross-overs.
- Searched multiple databases (CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL, DAI) and clinical trial registries.
- Analyzed 51 studies involving 3396 infants, focusing on pain reactivity and regulation.
Main Results:
- Non-nutritive sucking, kangaroo care, and swaddling/facilitated tucking demonstrated significant reductions in pain reactivity for preterm and neonatal infants.
- These interventions also improved immediate pain-related regulation in preterm and neonatal infants.
- Significant heterogeneity was noted in some analyses, impacting confidence in findings.
Conclusions:
- Non-pharmacological interventions are effective in managing acute procedural pain in infants.
- Specific methods like non-nutritive sucking, kangaroo care, and swaddling offer significant benefits for pain management in preterm, neonate, and older infants.
Background:
Infant acute pain and distress is commonplace. Infancy is a period of exponential development. Unrelieved pain and distress can have implications across the lifespan.
Objectives:
To assess the efficacy of non-pharmacological interventions for infant and child (up to three years) acute pain, excluding breastmilk, sucrose, and music. Analyses accounted for infant age (preterm, neonate, older) and pain response (pain reactivity, pain-related regulation).
Search Strategy:
We searched CENTRAL in The Cochrane Library (2011, Issue 1), MEDLINE (1966 to April 2011), EMBASE (1980 to April 2011), PsycINFO (1967 to April 2011), Cumulative Index to Nursing and Allied Health Literature (1982 to 2011), Dissertation Abstracts International (1980 to 2011) and www.clinicaltrials.gov. We also searched reference lists and contacted researchers via electronic list-serves.
Selection Criteria:
Participants included infants from birth to three years. Only randomized controlled trials (RCTs) or RCT cross-overs that had a no-treatment control comparison were eligible for inclusion in the analyses. We examined studies that met all inclusion criteria except for study design (e.g. had an active control) to qualitatively contextualize results.
Data Collection And Analysis:
We refined search strategies with three Cochrane-affiliated librarians. At least two review authors extracted and rated 51 articles. Study quality ratings were based on a scale by Yates and colleagues. We analyzed the standardized mean difference (SMD) using the generic inverse variance method. We also provided qualitative descriptions of 20 relevant but excluded studies.
Main Results:
Fifty-one studies, with 3396 participants, were analyzed. The most commonly studied acute procedures were heel-sticks (29 studies) and needles (n = 10 studies). The largest SMD for treatment improvement over control conditions on pain reactivity were: non-nutritive sucking-related interventions (preterm: SMD -0.42; 95% CI -0.68 to -0.15; neonate: SMD -1.45, 95% CI -2.34 to -0.57), kangaroo care (preterm: SMD -1.12, 95% CI -2.04 to -0.21), and swaddling/facilitated tucking (preterm: SMD -0.97; 95% CI -1.63 to -0.31). For immediate pain-related regulation, the largest SMDs were: non-nutritive sucking-related interventions (preterm: SMD -0.38; 95% CI -0.59 to -0.17; neonate: SMD -0.90, 95% CI -1.54 to -0.25), kangaroo care (SMD -0.77, 95% CI -1.50 to -0.03), swaddling/facilitated tucking (preterm: SMD -0.75; 95% CI -1.14 to -0.36), and rocking/holding (neonate: SMD -0.75; 95% CI -1.20 to -0.30). The presence of significant heterogeneity limited our confidence in the lack of findings for certain analyses.
Authors' Conclusions:
There is evidence that different non-pharmacological interventions can be used with preterms, neonates, and older infants to significantly manage pain behaviors associated with acutely painful procedures.
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