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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: May 28, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

The UCSC Genome Browser.

Donna Karolchik1, Angie S Hinrichs1, W James Kent1

  • 1Center for Biomolecular Science and Engineering, University of California Santa Cruz, Santa Cruz, California.

Current Protocols in Human Genetics
|October 7, 2011
PubMed
Summary
This summary is machine-generated.

The University of California Santa Cruz (UCSC) Genome Browser offers a powerful web-based platform for visualizing genomic data and annotations. It facilitates genome analysis, data download, and custom track creation for research and education.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • The University of California Santa Cruz (UCSC) Genome Browser is a widely used web-based tool.
  • It displays genomic regions at various scales with aligned annotation tracks.

Purpose of the Study:

  • To describe the usage of the UCSC Genome Browser and Table Browser for genome analysis.
  • To guide users on downloading database tables and creating custom annotation tracks.

Main Methods:

  • Utilizing the UCSC Genome Browser for visualizing genomic data and annotations.
  • Employing the UCSC Table Browser for accessing, downloading, and manipulating database tables.
  • Uploading personal datasets as custom annotation tracks.

Main Results:

  • The Genome Browser integrates diverse annotations including gene predictions, sequence alignments, and variation data.
  • The Table Browser allows for detailed examination and manipulation of underlying genomic data.
  • Custom tracks can be created and displayed, enhancing personalized genome analysis.

Conclusions:

  • The UCSC Genome Browser and Table Browser are essential tools for comprehensive genome analysis.
  • These platforms support both standard and personalized data visualization for research and education.