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Related Concept Videos

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and refractory oxide ion...
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

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Related Experiment Video

Updated: May 28, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

Significant proteins affecting cerebral vasospasm using complementary ICPMS and MALDI-MS.

Renee N Easter1, Colin G Barry, Gail Pyne-Geithman

  • 1Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.

Metallomics : Integrated Biometal Science
|October 7, 2011
PubMed
Summary
This summary is machine-generated.

Researchers explored selenium

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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

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Last Updated: May 28, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Area of Science:

  • Neuroscience
  • Biochemistry
  • Metallomics

Background:

  • Cerebral vasospasm (CV) is a significant complication following subarachnoid hemorrhage (SAH) stroke, affecting over a million individuals annually.
  • The underlying causes and preventative strategies for CV remain areas of intense research interest.
  • Emerging evidence suggests a potential role for selenium in the development of cerebral vasospasm.

Purpose of the Study:

  • To investigate the proteome associated with cerebral vasospasm using advanced metallomics techniques.
  • To determine if selenium influences the proteins identified in patients with cerebral vasospasm.

Main Methods:

  • Utilized size exclusion chromatography coupled with inductively coupled plasma mass spectrometry (SEC-ICP-MS).
  • Employed liquid chromatography-matrix assisted laser desorption/ionization-time of flight/time of flight (LC-MALDI-TOF/TOF) mass spectrometry.
  • Analyzed cerebrospinal fluid (CSF) samples from three groups: healthy controls, SAH patients without CV, and SAH patients with CV.

Main Results:

  • Successfully identified proteins associated with cerebral vasospasm in patient CSF samples.
  • Preliminary findings suggest the applied metallomics techniques are effective for this type of analysis.
  • Further investigation is warranted to elucidate the specific role of selenium and identified proteins in CV pathogenesis.

Conclusions:

  • The study demonstrates the applicability of advanced metallomics techniques for exploring the proteomic landscape of cerebral vasospasm.
  • These methods provide a foundation for future research into the etiology and potential therapeutic targets for CV.
  • Further studies are needed to confirm the role of selenium and its impact on identified proteins in cerebral vasospasm.