Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Proteomic profiling reveals potential mechanisms regulating acquisition of luteolytic capacity in the bovine corpus luteum†.

Biology of reproduction·2026

Same author

Interferon tau-dependent and -independent changes in the bovine corpus luteum of early pregnancy†.

Biology of reproduction·2025

Same author

Influence of heat stress and fescue toxicosis on the pulmonary arterial pressure of beef heifers.

Journal of animal science·2025

Same author

Exploring the impacts of fescue toxicosis on the pulmonary arterial pressure of angus cows.

Journal of animal science·2024

Same author

Examining the long-term impacts of ergot alkaloids on fetal heifer development and subsequent growth and reproductive performance.

Journal of animal science·2024

Same author

Applications of large-scale molecular profiling techniques to the study of the corpus luteum.

Animal reproduction·2022

Search research articles

Related Experiment Video

Updated: May 28, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Luteal microenvironment directs resident T lymphocyte function in cows.

Daniel H Poole¹, Joy L Pate

¹Department of Animal Sciences, The Ohio State University/Ohio Agricultural Research and Development Center, Wooster, USA.

Biology of Reproduction

|October 7, 2011

Summary

This summary is machine-generated.

Resident T cells (RTC) in the corpus luteum (CL) differ from peripheral blood. Their phenotypes change during luteal regression and pregnancy, indicating CL influences immune cell populations.

More Related Videos

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Related Experiment Videos

Last Updated: May 28, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Area of Science:

Reproductive immunology
Cellular immunology
Endocrinology

Background:

The corpus luteum (CL) is a temporary endocrine organ with complex cellular interactions.
The specific role of resident T cells (RTC) within the CL is not well understood.
Existing research suggests in vitro interactions between peripheral T cells and luteal cells.

Purpose of the Study:

To isolate RTC from the bovine CL.
To investigate changes in RTC phenotypes during alterations in luteal function, including regression and pregnancy.
To elucidate the regulatory role of the CL microenvironment on lymphocyte populations.

Main Methods:

Quantitative flow cytometry was used to analyze lymphocyte phenotypes.
RTC were isolated from the CL of bovine ovaries.
Luteal regression was induced to observe changes in RTC populations.

Main Results:

RTC phenotypes in the CL significantly differed from peripheral blood, with a higher proportion of CD8(+) cells.
CD8αα(+) and γδ(+)CD8αα(+) RTC increased during luteal regression.
FOXP3(+) lymphocytes were more abundant in the CL and decreased with luteolysis.
Pregnancy led to an increase in CD8αβ(+) and γδ(+)CD8αβ(+) populations within the CL.

Conclusions:

The CL microenvironment actively regulates the recruitment and differentiation of specific lymphocyte types.
Understanding these interactions is crucial for reproductive function and broader lymphocyte regulation insights.
Ovarian immune cell dynamics offer insights into tissue-specific immune responses.