Related Experiment Video
Updated: May 28, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Malaria hidden in a patient with diffuse large-B-cell lymphoma and sickle-cell trait
María Linares1, Enriqueta Albizua, Darío Méndez
1Department of Biochemistry and Molecular Biology IV and Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain. jmbau@vet.ucm.es.
Abstract:
We report a case of an African patient with sickle cell trait who was diagnosed in Spain with B-cell lymphoma. Blood smears were negative for malaria, and no plasmodium antigens were detected in the blood. To treat his lymphoma, the patient underwent chemotherapy and autologous stem cell transplantation. Following a splenectomy due to a worsening condition, he developed clinical malaria with detectable parasitemia. This case suggests that the humoral response and parasite removal by the spleen may afford protection from overt disease and may even help maintain subclinical human reservoirs of the disease.
Related Concept Videos
Malaria
Leishmaniasis
Symbiosis
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Cryptococcal Meningitis
Antiprotozoal Agents
