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High prevalence of sinusitis in children with henoch-schönlein purpura

Haruna Nakaseko1, Osamu Uemura, Takuhito Nagai

  • 1Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada Myoken-Cho, Obu, Aichi 474-8710, Japan.

International Journal of Pediatrics
|October 7, 2011
PubMed

Insights

Infectious foci like sinusitis are common in children with Henoch-Schönlein Purpura (HSP). Aggressive treatment of these infections reduced the incidence of nephritis in HSP patients.

Area of Science:

  • Pediatrics
  • Nephrology
  • Infectious Diseases

Background:

  • Henoch-Schönlein Purpura (HSP) is a common vasculitis in children.
  • Infectious foci, particularly in the upper respiratory tract and oral cavity, are suspected triggers for HSP.
  • Renal involvement (nephritis) is a significant complication of HSP.

Purpose of the Study:

  • To determine the prevalence and types of infectious foci in children diagnosed with HSP.
  • To investigate the incidence of renal involvement in HSP patients undergoing active treatment for identified infectious foci.
  • To assess if early intervention for infectious foci impacts the development of nephritis in HSP.

Main Methods:

  • A retrospective study of 96 children diagnosed with HSP at Aichi Children's Health and Medical Center.
  • Evaluation for infectious foci in the ear, nose, throat, and oral cavities.
  • Monitoring of renal involvement (nephritis) in patients, particularly those treated for infectious foci.

Main Results:

  • A high prevalence of infectious foci was observed in 74.0% of the 96 HSP patients.
  • Sinusitis was the most common infectious focus, present in 53.7% of cases.
  • In 44 HSP patients without initial renal involvement, aggressive treatment of infectious foci was associated with a lower incidence of nephritis (13.6%) compared to historical data.

Conclusions:

  • Infectious foci are highly prevalent in children with Henoch-Schönlein Purpura.
  • Early and aggressive intervention for infectious foci may reduce the risk of developing nephritis in HSP patients.
  • Targeting infections in the ear, nose, throat, and oral cavities is a crucial aspect of managing HSP in children.

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