Related Experiment Video
Updated: May 28, 2026
Clinical Efficacy of Ultrasound-Assisted Scoliosis-Specific Exercise in Mild-Grade Adolescent Idiopathic Scoliosis
Published on: December 2, 2025
Introduction:
Generalized low bone mass and osteopenia in both axial and peripheral skeleton in adolescent idiopathic scoliosis (AIS) have been reported in literature. However, the exact mechanisms and causes of the bone loss in AIS are not identified yet.
Objective:
Therefore, this study examined the relationship between AIS and bone loss represented by: serum concentration of soluble receptor activator of nuclear factor-kB ligand (RANKL), serum level of osteoprotegerin (OPG), serum level of osteocalcin (OST), parathormon (PTH) and BMI.
Materials And Methods:
We analyzed 15 patients with AIS and compared to the group of 8, age and gender-matched healthy controls. The bone markers in patients with AIS were disturbed compared with than in control individuals. Statistical analysis was performed by using t-test for independent samples.
Results:
The mean RANKL and RANKL to OPG ratio in patients with AIS were increased compared with that in control subjects. The RANKL and RANKL to OPG ratios were negatively correlated to serum OPG levels in both groups. These findings mean that the imbalance and the disturbed interaction of RANKL and OPG may be an important cause and pathogenesis in osteopenia in AIS.
Conclusion:
Research date showed an important correlation between osteopenia and AIS. The level significant higher of osteocalcin (p<0.01) and RANKL (p<0.01) was observed at adolescents with idiopathic scoliosis comparing with control group. OPG show no differences between the groups of study. RANKL/OPG ratio was significant higher compared with control group. Higher levels of RANKL, in the presence of increased levels of osteocalcin, may induce modification in bone remodelling due to imbalance in RANKL/OPG system.
More Related Videos
07:12Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis
Published on: February 10, 2026
08:08Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
Published on: October 16, 2013
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:28Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:31Osteoclasts in Bone Remodeling
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:22The Functions of the Skeletal System