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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
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Association between Cystatin C and MRI Measures of Left Ventricular Structure and Function: Multi-Ethnic Study of

Subhashish Agarwal1, Vinay Thohan, Michael G Shlipak

  • 1Department of Cardiology, Wake Forest University, Winston-Salem, NC 27157, USA.

International Journal of Nephrology
|October 7, 2011
PubMed

Insights

Elevated cystatin C, a marker of kidney dysfunction, is linked to reduced left ventricular volumes (LVEDV and LVESV). This pattern of concentric remodeling may explain how kidney issues contribute to heart failure.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Reduced kidney function is associated with heart failure and cardiovascular mortality.
  • The mechanisms linking kidney dysfunction to cardiac issues remain unclear.
  • Cystatin C is a marker for kidney function.

Purpose of the Study:

  • To investigate the relationship between cystatin C and subclinical left ventricular (LV) remodeling.
  • To explore these associations across diverse ethnic populations.

Main Methods:

  • Utilized data from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (N=4,970).
  • Measured cystatin C and LV parameters (LVEDV, LVESV, LVM, concentricity, LVEF) via MRI.
  • Employed nested linear models, adjusting for demographics and cardiovascular risk factors.

Main Results:

  • Higher cystatin C quartiles showed a linear association with lower LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV).
  • A significant inverse relationship was found between cystatin C and LV concentricity.
  • No association was observed between cystatin C and LV mass (LVM) or LV ejection fraction (LVEF).

Conclusions:

  • Cystatin C levels are inversely associated with LVEDV and LVESV.
  • A disproportionate decrease in LVEDV relative to LVM suggests concentric left ventricular remodeling.
  • This remodeling pattern may partially explain the link between kidney dysfunction and heart failure.

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