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Updated: May 28, 2026

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Published on: March 10, 2018

Mechanisms regulating chemokine receptor activity.

Laura D Bennett1, James M Fox, Nathalie Signoret

  • 1Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, UK.

Immunology
|October 8, 2011
PubMed
Summary

Chemokine receptors guide immune cell movement, crucial for immunity and disease. This review details how their surface expression is regulated, impacting therapeutic strategies for cancer and inflammation.

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Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
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Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

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Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling
10:03

Rapid and Robust Analysis of Cellular and Molecular Polarization Induced by Chemokine Signaling

Published on: December 12, 2014

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Leukocyte (white blood cell) movement is vital for immune system function.
  • Chemokines and their receptors mediate directed cell migration (chemotaxis).
  • Dysregulated chemokine receptor activity contributes to diseases like cancer and inflammation.

Purpose of the Study:

  • To review molecular mechanisms regulating chemokine receptor surface expression.
  • To highlight the role of these mechanisms in immune cell function and disease.
  • To inform therapeutic strategies targeting chemokine receptors.

Main Methods:

  • Literature review of studies on chemokine receptor regulation.
  • Analysis of molecular processes from gene transcription to protein degradation.
  • Examination of post-translational modifications, multimerization, transport, and cross-talk.

Main Results:

  • Chemokine receptor surface expression is tightly controlled by multiple molecular mechanisms.
  • Regulation occurs at transcriptional, post-translational, and intracellular transport levels.
  • Interactions such as multimerization and cross-talk significantly influence receptor availability.

Conclusions:

  • Understanding chemokine receptor regulation is key to developing targeted therapies.
  • Modulating receptor surface expression offers potential treatment avenues for inflammatory diseases and cancer.
  • Further research into these regulatory pathways is essential for advancing immunotherapy.