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Related Concept Videos

Horizontal Gene Transfer01:27

Horizontal Gene Transfer

Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...

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Related Experiment Video

Updated: May 28, 2026

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

Horizontal gene transfer in herpesviruses identified by using support vector machine.

M Fu1, R Deng, J Wang

  • 1Bioengineering and Food Science Department, Guangdong University of Technology, Guangzhou, People's Republic of China.

Acta Virologica
|October 8, 2011
PubMed
Summary

Horizontal gene transfer (HGT) introduces new genes, aiding genome evolution. This study developed a Support Vector Machine (SVM) method to identify HGT genes in herpesviruses with over 95% accuracy.

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Last Updated: May 28, 2026

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

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Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

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Area of Science:

  • Genomics
  • Bioinformatics
  • Evolutionary Biology

Background:

  • Horizontal gene transfer (HGT) is a significant source of novel genes.
  • Identifying HGT-introduced genes aids in understanding genome evolution and gene function prediction.

Purpose of the Study:

  • To develop and validate a computational method for identifying horizontally transferred genes in mammalian herpesviruses.
  • To distinguish between HGT-introduced and non-HGT genes using sequence composition analysis.

Main Methods:

  • Utilized a Support Vector Machine (SVM) algorithm.
  • Analyzed atypical gene composition to identify horizontally transferred genes.
  • Method validated for accuracy and efficiency on common personal computers.

Main Results:

  • Achieved identification accuracy exceeding 95% for HGT genes.
  • Identified 302 putative horizontally transferred genes, with 171 being novel discoveries.
  • Many identified genes are predicted to encode glycoproteins or membrane proteins, despite unknown functions for most.

Conclusions:

  • The SVM-based method provides an accurate and efficient approach for detecting HGT-introduced genes in herpesviruses.
  • This research expands the catalogue of HGT genes in mammalian herpesviruses, offering insights into their origins and potential functions.