Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Czechoslovak/Prague School of Immunology.

Folia microbiologica·2026
Same author

Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation.

Nanomedicine : nanotechnology, biology, and medicine·2023
Same author

Adaptable polymerization platform for therapeutics with tunable biodegradability.

Acta biomaterialia·2023
Same author

Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis.

Journal of controlled release : official journal of the Controlled Release Society·2022
Same author

PCL-PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems.

Journal of materials chemistry. B·2020
Same author

Micelle-forming HPMA copolymer conjugates of ritonavir bound via a pH-sensitive spacer with improved cellular uptake designed for enhanced tumor accumulation.

Journal of materials chemistry. B·2020

Related Experiment Video

Updated: May 28, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Novel star HPMA-based polymer conjugates for passive targeting to solid tumors.

T Etrych1, J Strohalm, P Chytil

  • 1Institute of Macromolecular Chemistry, Prague, Czech Republic. etrych@imc.cas.cz

Journal of Drug Targeting
|October 8, 2011
PubMed
Summary

Novel star polymer-doxorubicin conjugates show enhanced tumor targeting and anti-cancer activity in mice. These drug delivery systems improve circulation and accumulation, leading to superior efficacy compared to traditional doxorubicin treatments.

More Related Videos

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Related Experiment Videos

Last Updated: May 28, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Area of Science:

  • Polymer Chemistry
  • Nanomedicine
  • Cancer Therapeutics

Background:

  • Developing effective cancer treatments requires targeted drug delivery to minimize side effects.
  • Polymer conjugates offer potential for improved pharmacokinetics and tumor accumulation.
  • Doxorubicin (Dox) is a potent chemotherapy agent with limitations in its free form.

Purpose of the Study:

  • To synthesize and characterize novel star polymer-doxorubicin conjugates for passive tumor targeting.
  • To investigate the drug release mechanisms, biodistribution, and in vivo efficacy of these conjugates.
  • To evaluate the influence of polymer architecture on anti-tumor activity.

Main Methods:

  • Synthesis of star polymer conjugates using poly(amido amine) (PAMAM) dendrimers and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers.
  • Attachment of doxorubicin (Dox) via pH-sensitive hydrazone bonds or enzyme-cleavable GFLG sequences.
  • Physico-chemical characterization, drug release studies, biodistribution in tumor-bearing mice, and in vivo anti-tumor efficacy assessments.

Main Results:

  • Star polymer-Dox conjugates were successfully synthesized with controlled molecular weights.
  • Conjugates demonstrated prolonged blood circulation and enhanced tumor accumulation, indicative of the EPR effect.
  • Significantly higher anti-tumor activity was observed with star polymer-Dox conjugates compared to free Dox or linear conjugates.
  • Treatment effectiveness was influenced by tumor model type, with lower success in chronic tumor models.

Conclusions:

  • Star polymer-doxorubicin conjugates represent a promising strategy for passive tumor targeting and enhanced cancer therapy.
  • The star architecture and specific drug linkage are crucial for improved efficacy.
  • Further studies are warranted to optimize these conjugates for clinical application, considering tumor characteristics.