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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Candida in oral pre-cancer and oral cancer
P R Sanjaya1, S Gokul, B Gururaj Patil
1Department of Oral Pathology and Microbiology, Drs Sudha and Nageshwara Rao Siddhartha Institute of Dental Sciences and Hospital, Chinnaouutpalli, Gannavaram Mandal 521 286, Vijayawada, Krishna District, Andhra Pradesh, India. drsanjaynayak@gmail.com
Abstract:
Oral pre-malignancies and carcinomas are common epithelial pathologies caused by a variety of etiological factors. In the oral cavity, candidiasis is the most frequent opportunistic fungal infection. Since the initial reports of an association between candidiasis with oral pre-cancer and cancer, various theories have been debated regarding the role of candida in development and transformation of oral pre-malignancies. However, the exact role is still unclear. In the present article, we hypothesize a causal role for candidiasis in oral pre-cancer and cancer albeit an indirect one. We also suggest that candida along with other co-factors may play a role in initiation and promotion of carcinogenesis.
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