Therapeutic drug monitoring: focus on conditions in Indonesia

It has been long recognized that large inter-individual variability is commonly observed in response to drug administration. The large response variability of certain drugs with narrow margin of safety may induce toxicity. To avoid this and to optimize the result of drug treatment, therapeutic drug monitoring (TDM) service has been routinely applied in hospitals in well-developed countries. For certain drugs, the TDM service has been shown beneficial and cost-effective. In Indonesia, the TDM has not yet been implemented. There are three problems that hamper the implementation of TDM here, i.e. cost, the limited expertise to provide interpretation for result of drug assay, and the lack of communication with the clinicians. Today the patient safety issue is considered of paramount importance in the health care service in all hospitals. Therefore, it is now the time to commence the TDM service in Indonesia. This can be started with a pilot project in a large hospital, followed by the others. To avoid unnecesary wasting of funds, TDM should be limited for drugs which toxicity is not readily observed clinically.