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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[Diagnosis and treatment of ANCA-associated vasculitis : S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for ENT Medicine and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

Zeitschrift fur Rheumatologie·2025
Same author

[Diagnosis and treatment of ANCA-associated vasculitis : SHORT VERSION of the S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for Otorhinolaryngology and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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[T-cells in ANCA-associated vasculitis].

P Lamprecht1, D Kabelitz

  • 1Poliklinik für Rheumatologie, Vaskulitiszentrum UKSH & Klinikum Bad Bramstedt, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. peter.lamprecht@uk-sh.de

Zeitschrift Fur Rheumatologie
|October 8, 2011
PubMed
Summary

Granulomatosis with polyangiitis involves T-cells damaging blood vessels, with specific T-cells showing a Th17 cytokine profile. The anti-interleukin-5 antibody mepolizumab is effective in treating Churg-Strauss syndrome.

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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Immunology
  • Pathogenesis of autoimmune diseases

Background:

  • Granulomatosis with polyangiitis (Wegener's) pathogenesis is complex.
  • The role of specific T-cell subsets in endothelial damage is under investigation.

Purpose of the Study:

  • To elucidate the role of CD4+NKG2D+effector memory T-cells in granulomatosis with polyangiitis.
  • To characterize the cytokine profile of PR3-specific T-cells in this condition.

Main Methods:

  • Analysis of T-cell subsets and their function.
  • Cytokine profiling of antigen-specific T-cells.

Main Results:

  • CD4+NKG2D+effector memory T-cells may cause endothelial cell damage.
  • A Th17-dominated cytokine profile was observed in PR3-specific T-cells.

Conclusions:

  • These T-cell responses are implicated in granulomatosis with polyangiitis pathogenesis.
  • The anti-interleukin-5 antibody mepolizumab shows efficacy in Churg-Strauss syndrome, suggesting potential therapeutic avenues.