Related Experiment Video

Updated: May 28, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

[Effect of weight reduction on respiratory function in obese children with asthma]

Natsuko Masumoto1, Hiroshi Odajima, Kiyotaka Shimada

  • 1The Departmant of Pediatrics, National Fukuoka Hospital, Japan.

Arerugi = [Allergy]
|October 8, 2011
PubMed

Insights

Weight reduction improves lung function in obese children with asthma. Lowering body mass index (BMI), body fat percentage, and fat volume positively impacts respiratory parameters like forced vital capacity (FVC) and forced expiratory volume in one second (FEV1).

Area of Science:

  • Pediatric Pulmonology
  • Obesity Medicine
  • Respiratory Physiology

Context:

  • The link between childhood obesity and asthma is established, but underlying mechanisms require further investigation.
  • Previous studies indicate weight loss benefits adult lung function, yet systematic research in children is lacking.
  • This study focuses on the impact of weight reduction interventions on respiratory health in pediatric asthma patients.

Purpose:

  • To investigate the effect of a structured weight reduction program on respiratory function in obese children diagnosed with asthma.
  • To determine correlations between changes in obesity markers (BMI, %Fat, Fat volume) and respiratory parameters (FVC, FEV1, PEF, V50).

Summary:

  • Ten obese children (aged 7-13) with asthma participated in a weight reduction program.
  • Measurements included spirometry, BMI, %Fat, and Fat volume before and after the intervention.
  • Logistic linear analysis revealed significant correlations between reduced obesity markers and improved lung function, specifically %FVC and %FEV1.

Impact:

  • Weight reduction interventions can significantly enhance respiratory function in obese children with asthma.
  • Findings suggest that obesity exacerbates asthma symptoms, highlighting the therapeutic potential of weight management.
  • This research provides evidence for integrating weight control strategies into asthma management plans for pediatric populations.
Abstract

More Related Videos

Assessment of Child Anthropometry in a Large Epidemiologic Study09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...