Related Experiment Video
Updated: May 28, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Experimental hyperlipemia induces insulin resistance in cats
Naohito Nishii1, Haruka Maeda, Yusuke Murahata
1Laboratory of Veterinary Pharmacotherapeutics, Faculty of Agriculture, Tottori University, 4–101 Koyama-minami, Tottori 680–5883, Japan. nnishii@muses.tottori-u.ac.jp
Abstract:
The effect of experimental hyperlipemia on insulin sensitivity was evaluated in seven healthy cats. Serum triglyceride and free fatty acid concentrations were significantly (P<0.05) higher when lipid-heparin was administered (2,894 ± 1,526 mg/dl and 4.54 ± 0.70 mEq/l, respectively) than when saline was administered (70 ± 42 mg/dl and 0.22 ± 0.08 mEq/l, respectively). A glucose clamp test revealed that the mean glucose infusion rate when lipid-heparin was administered (5.80 ± 0.67 mg/kg/min) was significantly (P<0.05) lower than when saline was administered (8.52 ± 1.83 mg/kg/min). These results suggest that experimental hyperlipemia induced insulin resistance in the healthy cats.
More Related Videos
Related Concept Videos
Type II Diabetes II: Pathophysiology
Hyperglycemia

