Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Channels01:19

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Graphene Deformations Induced by Bucky-Ball and Bucky-Bowl Interactions.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Including population and environmental dynamic heterogeneities in continuum models of collective behaviour with applications to locust foraging and group structure.

PLoS computational biology·2025
Same author

Exploring carbon catenoids and their applications for encapsulation of carbon nanostructures.

PloS one·2024
Same author

Catalytic effect of graphene on the inversion of corannulene using a continuum approach with the Lennard-Jones potential.

Nanoscale advances·2023
Same author

Modeling Ultrafast Transport of Water Clusters in Carbon Nanotubes.

ACS omega·2023
Same author

Continuum Modeling with Functional Lennard-Jones Parameters for Methane Storage inside Various Carbon Nanostructures.

ACS omega·2022

Related Experiment Video

Updated: May 28, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Modelling peptide nanotubes for artificial ion channels.

Fainida Rahmat1, Ngamta Thamwattana, Barry J Cox

  • 1Nanomechanics Group, School of Mathematics and Applied Statistics, University of Wollongong, NSW 2522, Australia. fr498@uowmail.edu.au

Nanotechnology
|October 8, 2011
PubMed
Summary

D,L-Ala cyclopeptide nanotubes selectively interact with ions and C(60) fullerenes based on size. This research informs the design of peptide nanotubes for targeted drug delivery applications.

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
07:49

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Published on: January 22, 2019

Related Experiment Videos

Last Updated: May 28, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
07:49

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Published on: January 22, 2019

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Computational Chemistry

Background:

  • Cyclic peptides can self-assemble into nanotubes with potential applications in nanotechnology.
  • Understanding the interaction of these nanotubes with various molecules is crucial for their functionalization.

Purpose of the Study:

  • To investigate the van der Waals interactions between D,L-Ala cyclopeptide nanotubes and different guest molecules, including ions, ion-water clusters, and C(60) fullerenes.
  • To determine the factors influencing the encapsulation or rejection of these guests by peptide nanotubes.
  • To explore the potential of peptide nanotubes in drug delivery systems.

Main Methods:

  • Utilized the Lennard-Jones potential to model van der Waals interactions.
  • Employed a continuum approach, smearing atoms to represent average atomic density.
  • Simulated interactions with specific ions (Li+, Na+, Rb+, Cl-), ion-water clusters, and C(60) fullerenes within nanotubes of varying internal diameters (8.5 Å and 13 Å).

Main Results:

  • Peptide nanotubes with an 8.5 Å internal diameter accepted Li+, Na+, Rb+, Cl- ions, and ion-water clusters, but rejected C(60) fullerenes.
  • C(60) fullerenes were accepted into larger peptide nanotubes with a 13 Å internal diameter.
  • Interaction energy was found to be dependent on both the guest molecule size and the nanotube's internal diameter.
  • Ions showed a preference for specific low-energy positions within the peptide ring, while Li+-water clusters favored the inter-ring space.

Conclusions:

  • The size of both the guest molecule and the peptide nanotube's internal diameter dictates interaction outcomes.
  • Peptide nanotubes exhibit selective binding capabilities, with potential for size-based molecular recognition.
  • These findings support the development of peptide nanotubes as tailored platforms for drug delivery and molecular separation.