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Related Experiment Video

Updated: May 28, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Prevention of root caries.

Patrick Sequeira-Byron¹, Adrian Lussi

¹Department of Preventive, Restorative and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland.

Evidence-Based Dentistry

|October 8, 2011

Summary

Silver diamine fluoride (SDF), sodium fluoride varnish, and chlorhexidine varnish effectively prevent root caries in elders. These treatments, alongside oral hygiene, offer superior protection compared to oral hygiene instruction alone.

Area of Science:

Geriatric Dentistry
Preventive Dentistry
Cariology

Background:

Root caries is a significant oral health issue in institutionalized elders.
Effective preventive strategies are crucial for maintaining oral health in this population.

Discussion:

This randomized controlled trial compared four interventions: oral hygiene instruction (OHI) alone, OHI with chlorhexidine varnish, OHI with sodium fluoride varnish, and OHI with silver diamine fluoride (SDF) solution.
Treatments were applied to exposed root surfaces, with varying application frequencies.
Root Caries Index (RCI), prevented fraction (PF), relative risk, and number needed to treat (NNT) were used to assess efficacy.

Key Insights:

All three active treatments (chlorhexidine, sodium fluoride, SDF) demonstrated significantly lower risks of developing new root caries compared to OHI alone.

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Last Updated: May 28, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

SDF showed the lowest mean number of new root caries surfaces, followed by sodium fluoride and chlorhexidine.

The study supports the use of these agents in clinical and community settings for root caries prevention.

Outlook:

Further research could explore long-term efficacy and cost-effectiveness of these preventive agents.
Integration of these treatments into routine geriatric dental care protocols is recommended.
Investigating patient acceptance and adherence to different application regimens may be beneficial.