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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 28, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Comparative human aqueous dynamics study between black and white subjects with glaucoma.

Laura Beltran-Agullo1, Pouya Alaghband, Safina Rashid

  • 1Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.

Investigative Ophthalmology & Visual Science
|October 8, 2011
PubMed
Summary
This summary is machine-generated.

Aqueous humor dynamics in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) patients showed no significant racial differences. However, thinner corneas in Black patients may affect intraocular pressure (IOP) and outflow measurements.

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Ocular Physiology

Background:

  • Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) are leading causes of vision loss.
  • Understanding baseline aqueous humor dynamics is crucial for glaucoma management.
  • Racial variations in ocular parameters may influence disease presentation and progression.

Purpose of the Study:

  • To compare baseline aqueous humor dynamics between white Caucasian and Black patients with untreated POAG or OHT.
  • To investigate potential racial differences in intraocular pressure (IOP), aqueous flow, and outflow facility.

Main Methods:

  • Prospective, observational controlled study of 91 participants (POAG/OHT patients and healthy controls).
  • Measurements included intraocular pressure (IOP), aqueous humor flow rate, and trabecular outflow facility.
  • Uveoscleral outflow was calculated, and statistical analyses compared racial groups.

Main Results:

  • No significant differences in IOP, outflow facility, aqueous flow, or uveoscleral outflow were found between white and Black POAG/OHT groups.
  • POAG/OHT groups exhibited higher IOP and lower outflow facility than healthy controls.
  • Black participants had significantly thinner corneas compared to white participants.

Conclusions:

  • Baseline aqueous humor dynamics do not significantly differ between Black and white patients with POAG or OHT.
  • Thinner corneas in Black patients may confound IOP and outflow facility measurements.
  • Further research is needed to account for corneal thickness in racial comparisons of glaucoma parameters.